Where objective measurement may add value

Selected publications

• Evaluating biomarkers and prediction models with E2P Simulator

  Karvelis, P., Felsky, D., Abi-Dargham, A., Horga, G., & Diaconescu, A. O.

  2026 · eLife

• E2P Simulator: An interactive tool for translating effect sizes into predictive utility

  Karvelis, P., & Diaconescu, A. O.

  2025 · Journal of Open Source Software

• Clarifying the reliability paradox: poor measurement reliability attenuates group differences

  Karvelis, P., & Diaconescu, A. O.

  2025 · Frontiers in Psychology

• Test-retest reliability of behavioral and computational measures of advice taking under volatility

  Karvelis, P., Hauke, D. J., Wobmann, M., Andreou, C., Mackintosh, A., de Bock, R., Borgwardt, S., Roth, V., & Diaconescu, A. O.

  2024 · PLOS ONE

• Individual differences in computational psychiatry: a review of current challenges

  Karvelis, P., Paulus, M. P., & Diaconescu, A. O.

  2023 · Neuroscience & Biobehavioral Reviews

• Computational approaches to treatment response prediction in major depression using brain activity and behavioral data: a systematic review

  Karvelis, P., Charlton, C. E., Allohverdi, S. G., Bedford, P., Hauke, D. J., & Diaconescu, A. O.

  2022 · Network Neuroscience

• Increased belief instability in psychotic disorders predicts treatment response to metacognitive training

  Hauke, D. J., Roth, V., Karvelis, P., Adams, R. A., Moritz, S., Borgwardt, S., Diaconescu, A. O., & Andreou, C.

  2022 · Schizophrenia Bulletin

• Comparative computational modeling of approach–avoidance biases in suicidal populations via hierarchical Bayesian inference

  Laessing, P., Karvelis, P., Kennedy, J., Zai, C. C., Dayan, P., & Diaconescu, A. O.

  2025 · bioRxiv

Selected publications

• Aberrant hierarchical prediction errors are associated with transition to psychosis: a computational single-trial analysis of the mismatch negativity

  Hauke, D. J., Charlton, C. E., Schmidt, A., Griffiths, J., Woods, S. W., Ford, J. M., Srihari, V. H., Roth, V., Diaconescu, A. O., & Mathalon, D. H.

  2023 · Biological Psychiatry: CNNI

• Altered perception of environmental volatility during social learning in emerging psychosis

  Hauke, D. J., Wobmann, M., Andreou, C., Mackintosh, A., de Bock, R., Karvelis, P., Adams, R. A., Sterzer, P., Borgwardt, S., Roth, V., & Diaconescu, A. O.

  2024 · Computational Psychiatry

• Atypical prediction error learning is associated with prodromal symptoms in individuals at clinical high risk for psychosis

  Charlton, C. E., Lepock, J. R., Hauke, D. J., Mizrahi, R., Kiang, M., & Diaconescu, A. O.

  2022 · Schizophrenia

• Neural dynamics of social cognition: a single-trial computational analysis of learning under uncertainty

  Charlton, C. E., Hauke, D. J., Litvak, V., Wobmann, M., Andreou, C., de Bock, R., Borgwardt, S., Rothe, V., & Diaconescu, A. O.

  2026 · Human Brain Mapping

• Atypical processing of uncertainty in individuals at risk for psychosis

  Cole, D. M., Diaconescu, A. O., Pfeiffer, U. J., Brodersen, K. H., Mathys, C. D., Julkowski, D., Ruhrmann, S., Schilbach, L., Tittgemeyer, M., Vogeley, K., & Stephan, K. E.

  2020 · NeuroImage: Clinical

• Models of persecutory delusions: a mechanistic insight into the early stages of psychosis

  Diaconescu, A. O., Hauke, D. J., & Borgwardt, S.

  2019 · Molecular Psychiatry

Selected publications

• Characterizing suicidal thoughts and behaviours in individuals presenting to a psychiatric emergency department: a protocol for a multimethod approach for suicide prevention research

  Baharikhoob, A., Maslej, M., Wong, A., Mulsant, B. H., Blumberger, D. M., Courtney, D., Husain, M., Kurdyak, P., Kleinman, R. A., et al., including Diaconescu, A. O.

  2025 · BMJ Open

• A computational model of hopelessness and active-escape bias in suicidality

  Karvelis, P., & Diaconescu, A. O.

  2022 · Computational Psychiatry

• Comparative computational modeling of approach–avoidance biases in suicidal populations via hierarchical Bayesian inference

  Laessing, P., Karvelis, P., Kennedy, J., Zai, C. C., Dayan, P., & Diaconescu, A. O.

  2025 · bioRxiv

Selected publications

• The Toronto Adolescent and Youth Cohort Study: study design and early data related to psychosis spectrum symptoms, functioning, and suicidality

  Cleverley, K., Foussias, G., Ameis, S. H., Diaconescu, A. O., et al.

  2023 · Biological Psychiatry: CNNI

• Neuroimaging and biosample collection in the Toronto Adolescent and Youth (TAY) Cohort Study: rationale, methods, and early data

  Dickie, E. W., Ameis, S. H., Boileau, I., Diaconescu, A. O., Felsky, D., Goldstein, B. I., et al.

  2023 · Biological Psychiatry: CNNI

• Characterization and prediction of individual functional outcome trajectories in schizophrenia spectrum disorders (PREDICTS study): study protocol

  Agarwal, S. M., Dissanayake, J., Agid, O., Bowie, C., including Diaconescu, A. O., et al.

  2023 · PLOS ONE

• Test-retest reliability of behavioral and computational measures of advice taking under volatility

  Karvelis, P., Hauke, D. J., Wobmann, M., et al., & Diaconescu, A. O.

  2024 · PLOS ONE

• Localizing hierarchical prediction errors and precisions during an oddball task with volatility: computational insights and relationship with psychosocial functioning

  Charlton, C. E., Hauke, D. J., Wobmann, M., Andreou, C., de Bock, R., Borgwardt, S., Roth, V., & Diaconescu, A. O.

  2025 · Imaging Neuroscience

• Human aging alters social inference about others' changing intentions

  Reiter, A. M. F., Diaconescu, A. O., Eppinger, B., & Li, S.-C.

  2021 · Neurobiology of Aging